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GPCA Funded Grants

Each year the Canine Health Foundation presents lists of research needing funding to the GPCA Health Committee. The committee reviews the proposals and through discussion and member votes, chooses those beneficial to Great Pyrenees or general canine health. Though many have been chosen with the expectation they will add to the knowledge of cause or cure of cancers reported in Great Pyrenees, many will benefit other health concerns.

GPCA Studies/Research – 2020

Currently Funded

 

Grant 01660: Identify the Genes That Confer Risk for Osteosarcoma PDF file End of Year 8 Report

Grant 01780: Defining the Mechanism by Which Ticks Locate Dogs in Order to Better Prevent Disease Transmission PDF file Final Report

Grant 02383: Identifying Cellular Mechanisms of Inflammation During Canine Tick-Borne Diseases PDF file Final Report

Grant 02518: The Effects of Early Life Experience on Working Dog Tempermant and Cognition PDF file Mid -Year 2 Report

Grant 02519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangosarcomas Within and Between Geographic Locations PDF file End of Year 2 Report

Grant 02528: Developing a Next Generation Sequencing Diagnostic Platform for Tick-Borne Diseases PDF file Mid-Year 2 Report

Grant 02534: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma PDF file Mid-Year 1 Report

Grant 02659: Breed Specific Reference Ranges for Canine Thyroid Testing PDF file Mid-Year 1 Report

GPCA Funded Studies/Research – 2016

Gastrointestinal Disease Research Program Area


Grant 02233-A: Evaluation of a Novel Technique for Gastric Decompression in Dogs with
Gastric Dilatation and VolvulusPDF file<

Grant 01935-B: Abnormalities in the Stomach's Ability to Contract Predisposes Large-Breed Dogs to BloatPDF file

Grant 01937-B: Evaluating the Complex Genetic Basis of BloatPDF file

Grant 02215: A Cancer Vaccine for Canine OsteosarcomaPDF file

NOTE: None of the above studies are requesting samples from Great Pyrenees, and the results are not expected to be breed-specific.

Studies/Research Closed or Completed, Previously Funded by GPCA


Grant No. 2078: Development of a Regenerative Medicine Technique to Treat Cartilage Disorders in Dogs
Final Downloadable ReportPDF file

Grant No. 01139: Immune Targeting of Canine Hemangiosarcoma Using a Canine Derived Single Chain Antibody Approach
Final Downloadable ReportPDF file

Grant No. 00982: Evaluation of Efficacy of Fasaret in Dogs with Osteosarcoma
Final Downloadable ReportPDF file

Grant No. 01355: A Expression of Vascular Endothelial Markers in Canine Hemangiosarcoma and Their Use in Diagnostic Cytology Using Immunocytochemistry
Final Downloadable ReportPDF file

Grant No. 757A&B: Hereditary Mutations in Genes Associated with Osteosarcoma in Large Dog Breeds Final Downloadable ReportPDF file

Grant No. 976: Investigating the Role of STAT3 Activation in Canine Osteosarcoma
Final Downloadable ReportPDF file

Grant No. 373A: Mapping Genes Associated with Osteosarcoma in Large Dog Breeds - Research headed by Dr. Kerstin Linblad-Toh, The Broad Institute. Downloadable ReportPDF file

Grant No. 2405: Inhibition of Collagenolysis in Canine Cruiciate Ligament During Rupture - Research headed by Peter Muir, BVSc, PhD, University of Wisconsin. Downloadable ReportPDF file

Cancers Affecting the Great Pyrenees

Type of cancers affecting the Great Pyrenees vary. The most common, however, is osteosarcoma, with hemangiosarcoma rising behind it.

The GPCA currently co-funds research with The Broad Institute for osteosarcoma. This is a very important study, and the researchers are seeking samples of both affected and non-affected Great Pyrenees.

The Broad Institute is also conducting a study on various types of cancer — The Dog Genome Project. They are also seeking samples of both affected and non-affected Great Pyrenees for the following cancers:

  • Osteosarcoma
  • Hemangiosarcoma
  • Melanoma
  • Lymphoma
  • Mammary Cancer
  • Mast Cell