Health Information Center

GPCA Funded Grants

Each year the Canine Health Foundation presents lists of research needing funding to the GPCA Health Committee. The committee reviews the proposals and through discussion and member votes, chooses those beneficial to Great Pyrenees or general canine health. Though many have been chosen with the expectation they will add to the knowledge of cause or cure of cancers reported in Great Pyrenees, many will benefit other health concerns.

GPCA Studies/Research – 2020

Currently Funded

Grant 01660: Identify the Genes That Confer Risk for Osteosarcoma PDF file End of Year 8 Report

Grant 01780: Defining the Mechanism by Which Ticks Locate Dogs in Order to Better Prevent Disease Transmission PDF file Final Report

Grant 02383: Identifying Cellular Mechanisms of Inflammation During Canine Tick-Borne Diseases PDF file Final Report

Grant 02518: The Effects of Early Life Experience on Working Dog Tempermant and Cognition PDF file Mid -Year 2 Report

Grant 02519: Prevalence of Bartonella spp. Infection in Dogs with Cardiac and Splenic Hemangosarcomas Within and Between Geographic Locations PDF file End of Year 2 Report

Grant 02528: Developing a Next Generation Sequencing Diagnostic Platform for Tick-Borne Diseases PDF file Mid-Year 2 Report

Grant 02534: Clinical Trial for Evaluation of Propranolol and Doxorubicin in the Treatment of Canine Hemangiosarcoma PDF file Mid-Year 1 Report

Grant 02659: Breed Specific Reference Ranges for Canine Thyroid Testing PDF file Mid-Year 1 Report

GPCA Funded Studies/Research – 2016

Gastrointestinal Disease Research Program Area

Grant 02233-A: Evaluation of a Novel Technique for Gastric Decompression in Dogs with
Gastric Dilatation and Volvulus
PDF file<

Grant 01935-B: Abnormalities in the Stomach's Ability to Contract Predisposes Large-Breed Dogs to BloatPDF file

Grant 01937-B: Evaluating the Complex Genetic Basis of BloatPDF file

Grant 02215: A Cancer Vaccine for Canine OsteosarcomaPDF file

NOTE: None of the above studies are requesting samples from Great Pyrenees, and the results are not expected to be breed-specific.

Studies/Research Closed or Completed, Previously Funded by GPCA

Grant No. 2078: Development of a Regenerative Medicine Technique to Treat Cartilage Disorders in Dogs
Final Downloadable ReportPDF file

Grant No. 01139: Immune Targeting of Canine Hemangiosarcoma Using a Canine Derived Single Chain Antibody Approach
Final Downloadable ReportPDF file

Grant No. 00982: Evaluation of Efficacy of Fasaret in Dogs with Osteosarcoma
Final Downloadable Report
PDF file

Grant No. 01355: A Expression of Vascular Endothelial Markers in Canine Hemangiosarcoma and Their Use in Diagnostic Cytology Using Immunocytochemistry
Final Downloadable ReportPDF file

Grant No. 757A&B: Hereditary Mutations in Genes Associated with Osteosarcoma in Large Dog Breeds Final Downloadable ReportPDF file

Grant No. 976: Investigating the Role of STAT3 Activation in Canine Osteosarcoma
Final Downloadable ReportPDF file

Grant No. 373A: Mapping Genes Associated with Osteosarcoma in Large Dog Breeds - Research headed by Dr. Kerstin Linblad-Toh, The Broad Institute. Downloadable ReportPDF file

Grant No. 2405: Inhibition of Collagenolysis in Canine Cruiciate Ligament During Rupture - Research headed by Peter Muir, BVSc, PhD, University of Wisconsin. Downloadable ReportPDF file

Cancers Affecting the Great Pyrenees

Type of cancers affecting the Great Pyrenees vary. The most common, however, is osteosarcoma, with hemangiosarcoma rising behind it.

The GPCA currently co-funds research with The Broad Institute for osteosarcoma. This is a very important study, and the researchers are seeking samples of both affected and non-affected Great Pyrenees.

The Broad Institute is also conducting a study on various types of cancer — The Dog Genome Project. They are also seeking samples of both affected and non-affected Great Pyrenees for the following cancers:

  • Osteosarcoma
  • Hemangiosarcoma
  • Melanoma
  • Lymphoma
  • Mammary Cancer
  • Mast Cell
Information from the Broad Institute

Contact/instructions for submissions of blood or tissue samples for The Dog Genome Project, The DogDNA Project and the Broad Dog Disease Mapping Project or any of the above conditions are available here.

We are unable to reimburse for the cost of shipping or veterinary expenses, and we greatly appreciate your assistance with the research.

Please visit the Broad Institute website for more information on canine disease research. If you have questions please use this link to email them. Broad Institute Email

Collecting Samples

They prefer blood samples because it gives more DNA and much higher quality DNA.

Unfortunately, neither the Broad Institute or the GPCA can provide blood collection kits. To send a blood sample, you will need:

  1. 5 mL EDTA tube
  2. the consent form signed by the owner
  3. shipping materials

Please have your vet collect 5 mL of blood in the EDTA tube. Your vet should be able to provide the EDTA tube. Information for veterinarians

Please label the tube with the following information:

  • Dog's name
  • Breed
  • AKC number
  • Sex

If your dog has been sick, even if they are now healthy, please include copies of any diagnostic reports from your vet, including:

  • histopathology reports
  • blood tests
  • radiograph and ultrasound analysis

Shipping Samples

Ship the blood and the signed consent form to:

Dog Genome Project
Broad Institute
7 Cambridge Center
Cambridge, MA 02142

If possible, let us know to expect your sample:
     Fax: (617) 324-4987

When shipping blood samples, please be very careful to package it to prevent breakage and leaking. Tubes should be wrapped in soft material to pad the glass tubes, and then sealed in a ziploc bag (which will prevent any leaking if a sample tube is broken). Samples from multiple dogs may be shipped together but please ensure that the tubes are labeled clearly so that there will not be any confusion as to which dog the blood belongs to. Please use a box for the shipping that will not be crushed through normal handling by the post office (or any other carrier). Extra packing (i.e. some crumpled newspaper) should be added to the box to minimize movement of the tubes within the shipping box.

Please note that we must have a signed consent form for every dog participating in our research. We will also need the AKC number or pedigree information.

Additional Information

Many veterinarians are willing to collect additional blood for our research as part of routine bloodwork.

Even if less than 5 mL of blood is collected, please send the sample. Blood is very rich in DNA and as little as 2 mL can be sufficient.

If sending blood for multiple dogs with the same owner, the owner information can be filled out on just one consent form. It is critical, though, that for each dog we have a consent form with the dog's information and the owner/agent signature.

If you have questions please contact the Broad Institute at or Contact Flo Laicher at